Development of hybrid structures are gaining importance in order to reduce vehicle mass as it directly influences the energy consumption. Multiple materials are used to manufacture hybrid structures that make use of each material specific advantages. However, hybrid manufacturing are semi-automated process due to many challenges making it an expensive process. This paper address vacuum assisted resin transfer molding (VARTM) towards resource efficiency by reducing the material wastage (sealing material). Conventional VARTM method is used to produce complex fiber-reinforced plastics (FRP) and FRP-metal hybrid structures. According to the state of art, tools used to produce structures via VARTM are sealed using polymer materials to prevent the leakage of low viscosity matrix system. Such a seals undergo significant amount of thermal, chemical and mechanical wear. This results in constant monitoring of seals during production cycles as they need to be replaced in certain maintenance interval to prevent leakage resulting in downtime of production line for inspection and replacing. In order to overcome this challenge, this paper introduce a novel sealing concept for large volume manufacturing both FRP and hybrid structures replacing conventional polymer seals. The sealing is achieved by accelerating the curing of matrix system itself with the help of heating elements and catalysts resulting in a self-sealing technique/approach. The sealing concept is validated and optimized using experiments, simulations and analytical approaches.