Multi-material designs with tailored material properties, such as hybrid parts of metals and thermoplastics, are a key factor for implementing novel lightweight solutions, e.g. in the transportation sector. For improving adhesion between the components, the joining zone is often enlarged by applying different surface structuring methods. In this study, Ti-6Al-4V samples with different types of surface structures for interlocking were produced by electron beam melting. The obtained structures were characterized using optical microscopy. Thermal direct joining was used to connect those metal samples to fiber-reinforced PEEK. Moreover, titanium samples were adhesively bonded utilizing a one-component epoxy and a thermoplastic adhesive, respectively. Tensile shear tests were conducted and monitored via in-situ optical strain measurements by digital image correlation. The samples were exposed to salt spray testing for evaluating the influence of extreme environmental conditions on the bond strength. In this contribution, the high potential for lightweight applications will be discussed in-depth.